4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[5-[2-(1H-imidazol-1-yl)acetyl]-2-(1-methylethoxy)phenyl]-
Imidazole ketone erastin
CAS: 1801530-11-9
Molecular Formula: C35H35ClN6O5
4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[5-[2-(1H-imidazol-1-yl)acetyl]-2-(1-methylethoxy)phenyl]- - Names and Identifiers
4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[5-[2-(1H-imidazol-1-yl)acetyl]-2-(1-methylethoxy)phenyl]- - Physico-chemical Properties
| Molecular Formula | C35H35ClN6O5 |
| Molar Mass | 655.14 |
| Density | 1.34±0.1 g/cm3(Predicted) |
| Boling Point | 886.5±75.0 °C(Predicted) |
| Solubility | DMSO : 125 mg/mL (190.80 mM) |
| pKa | 6.12±0.10(Predicted) |
| Storage Condition | 2-8°C |
| In vivo study | In diffuse large B- cell lymphoma xenograft models, IKE inhibits system xc-, causes glutathione depletion, lipid peroxidation, and induces biomarkers of Iron death. |
4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[5-[2-(1H-imidazol-1-yl)acetyl]-2-(1-methylethoxy)phenyl]- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.526 ml | 7.632 ml | 15.264 ml |
| 5 mM | 0.305 ml | 1.526 ml | 3.053 ml |
| 10 mM | 0.153 ml | 0.763 ml | 1.526 ml |
| 5 mM | 0.031 ml | 0.153 ml | 0.305 ml |
Last Update：2024-01-02 23:10:35
4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[5-[2-(1H-imidazol-1-yl)acetyl]-2-(1-methylethoxy)phenyl]- - Reference Information
| biological activity | Imidazole ketone erastin (PUN30119, IKE) is an effective, metabolically stable, selective system xc-inhibitors as well as ferroptosis inducers. |
| Target | Value |
Last Update：2024-04-09 02:00:14
![4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[5-[2-(1H-imidazol-1-yl)acetyl]-2-(1-methylethoxy)phenyl]-](http://res.chembk.com/assets/str/2d/1/18/1801530-11-9.png)
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Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
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View History
4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[5-[2-(1H-imidazol-1-yl)acetyl]-2-(1-methylethoxy)phenyl]-
月桂基二亚乙二氨基甘氨酸盐酸盐
2-(四氢呋喃)乙酸
二氯乙二胺合铂
Triphenyl triaMinotriphenylcarbinol sulfonic acid sodiuM salt
RG3039
3(3-ALLYL)-5-HEXENENITRILE
3-叔丁氧酰胺基氮杂环庚烷
L-α-phosphatidylethanolaMine (Liver, Bovine)
1,3-Cyclopentanediol,4-(2-hydroxyethyl)-5-(hydroxymethyl)-1-methyl-,[1S-(1-alpha-,3-alpha-,4-bta-,5-bta-)]-(9CI)
月桂基二亚乙二氨基甘氨酸盐酸盐
2-(四氢呋喃)乙酸
二氯乙二胺合铂
Triphenyl triaMinotriphenylcarbinol sulfonic acid sodiuM salt
RG3039
3(3-ALLYL)-5-HEXENENITRILE
3-叔丁氧酰胺基氮杂环庚烷
L-α-phosphatidylethanolaMine (Liver, Bovine)
1,3-Cyclopentanediol,4-(2-hydroxyethyl)-5-(hydroxymethyl)-1-methyl-,[1S-(1-alpha-,3-alpha-,4-bta-,5-bta-)]-(9CI)